Progression of the PI3K/Akt signaling pathway in chronic obstructive pulmonary disease

Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by slow progression and caused the inhalation of harmful particulate matter. Cigarette smoke air pollutants are primary contributing factors. Currently, pathogenesis COPD remains incompletely understood. The PI3K/Akt signaling pathway has recently emerged as critical regulator inflammation oxidative stress response in COPD, playing pivotal role disease’s treatment. This paper reviews association between examines effective inhibitors novel anti-COPD agents, aiming to identify new therapeutic targets for clinical intervention this disease.